MELVILLE, NEW YORK, March 14, 2019 - FONAR Corporation (NASDAQ-FONR), The Inventor of MR Scanning™, reported today publication of a chapter where the physician-author-researchers utilized the FONAR UPRIGHT® Multi-Position™ MRI. The title of their chapter is: Craniocervical Junction Syndrome: Anatomy of the Craniocervical and Atlantoaxial Junctions and the Effect of Misalignment on Cerebrospinal Fluid Flow.

The chapter is in a book titled ‘Hydrocephalus - Water on the Brain’ and was published by IntechOpen, the world's leading publisher of Open Access books for scientists. The chapter can be found at: https://www.intechopen.com/books/hydrocephalus-water-on-the-brain/craniocervical-junction-syndrome-anatomy-of-the-craniocervical-and-atlantoaxial-junctions-and-the-ef. The authors are Drs. Scott Rosa, John W. Baird, David Harshfield and Mahan Chehrenama.

Dr. Rosa says: “The chapter describes how malformations and misalignments of the craniocervical junction (CCJ) can cause a constellation of cerebral and other neurological signs and symptoms collectively called the craniocervical syndrome (CCS). The signs and symptoms of the craniocervical junction syndrome, may be due to mechanical strain causing deformation of dura mater, vasculature and other structures of the cranial vault resulting in irritation of and dysfunction of affected tissues. Deformation of the CCJ may also obstruct blood and CSF flow. Chronic ischemia, edema and hydrocephalus can cause degenerative cascades that can in turn lead to neurodegenerative diseases.”

Dr. Rosa has developed a patented method to restore cerebrospinal integrity by correcting misalignments at the cranio-cervical junction (CCJ). The method is called Image Guided Atlas Treatment™ or IGAT™. He says that the FONAR UPRIGHT® MRI and its imaging sequences are a critical part of the IGAT™ methodology in correcting the misalignments found at the CCJ. This is because only the FONAR UPRIGHT® MRI can visualize the CCJ in the upright, fully weight-loaded position, necessary for detecting fully distended cerebellar tonsillar ectopia and CSF flow impeding vertebral malalignments.

Raymond V. Damadian, M.D., Chairman of the Board of Directors of FONAR Corporation, said: It is rewarding when we see our UPRIGHT® MRI scanner providing valuable results. When I went to medical school, little was known about CSF physiology. The MRI has visualized the flow of the CSF for the first time and enabled its quantification, thus providing a measure of the degree to which the therapy being employed is achieving its desired end results and enabling assessment of the therapy modifications that might be needed. Now we understand that 32 quarts of cerebrospinal fluid (CSF) per day originate in the ventricles of the brain and circulate down the spine to the sacrum and back.”

“I would like to thank the authors for this thorough research publication and their past and continued efforts towards the understanding of the “craniocervical syndrome” (CCS) and “craniocervical joint dysfunction”. FONAR’s own research validates their work. In the future, continued understanding of the CCS may plausibly have a significant impact on the genesis and treatments of the many neurodegenerative diseases that plague mankind. These include multiple sclerosis, amyotrophic lateral sclerosis (Lou Gehrig’s Disease), Alzheimer’s, Parkinson’s and additionally the non neurodegenerative disease childhood autism and birth injury Cerebral Palsy.” concluded Dr. Damadian.

Following are figures 6, 9 and 11 from the online Chapter 3. Figures 6 and 9 demonstrate an example of the cervical misalignment that can be realigned by IGAT™. Figure 11 shows a CSF flow cinematic MRI in the pre-IGAT™ and post-IGAT™ on the same patient. “All MRI images in the chapter 3 were taken on the FONAR UPRIGHT® Multi-Position™ MRI,” said Dr. Rosa.

This press release contains an actual CSF flow cinematic which is different from the static-only picture for Figure 11 in the online published chapter.

Figure 6.
Rotary misalignment of atlas (C1) and axis (C2)

Figure 9.
Coronal view demonstrating misalignment of C0-C1 with left cerebellar tonsillar ectopia.

Figure 11. (Single frame from CSF flow cinematic)
Disruption of CSF flow (left) with restoration of normal flow post IGAT (right)
on phase contrast cine CSF flow MR.

About FONAR
FONAR, The Inventor of MR Scanning™, is located in Melville, NY, was incorporated in 1978, and is the first, oldest and most experienced MRI company in the industry. FONAR introduced the world’s first commercial MRI in 1980, and went public in 1981.

The Company’s two industry segments are: development, manufacturing and servicing of the FONAR UPRIGHT® Multi-Position™ MRI, aka Stand-Up® MRI, and management of 26 MRI centers through its subsidiary, Health Management Company of America (HMCA).

FONAR’s signature product is the FONAR UPRIGHT® Multi-Position™ MRI (also known as the Stand-Up® MRI), the only whole-body MRI that performs Position™ Imaging (pMRI™) and scans patients in numerous weight-bearing positions, i.e. standing, sitting, in flexion and extension, as well as the conventional lie-down position. The FONAR UPRIGHT® MRI often detects patient problems that other MRI scanners cannot because they are lie-down and ”weightless” only scanners. The patient-friendly UPRIGHT® MRI has a near-zero patient claustrophobic rejection rate. As a FONAR customer states, “If the patient is claustrophobic in this scanner, they’ll be claustrophobic in my parking lot.” Approximately 85% of patients are scanned sitting while watching TV.

FONAR has new works-in-progress technology for visualizing and quantifying the cerebral hydraulics of the central nervous system, the flow of cerebrospinal fluid (CSF), which circulates throughout the brain and vertebral column at the rate of 32 quarts per day. This imaging and quantifying of the dynamics of this vital life-sustaining physiology of the body’s neurologic system has been made possible first by FONAR’s introduction of the MRI and now by this latest works-in-progress method for quantifying CSF in all the normal positions of the body, particularly in its upright flow against gravity. Patients with whiplash or other neck injuries are among those who will benefit from FONAR's new technology for quantifying CSF flow and the new clinical understanding it provides.

FONAR’s substantial list of patents includes recent patents for its technology enabling full weight-bearing MRI imaging of all the gravity sensitive regions of the human anatomy, especially the brain, extremities and spine. It includes its newest technology for measuring the Upright cerebral hydraulics of the central nervous system. FONAR’s UPRIGHT® Multi-Position™ MRI is the only scanner licensed under these patents.

UPRIGHT® and STAND-UP® are registered trademarks and The Inventor of MR Scanning™, Full Range of Motion™, Multi-Position™, Upright Radiology™, The Proof is in the Picture™, True Flow™, pMRI™, Spondylography™, Dynamic™, Spondylometry™, CSP™, and Landscape™, are trademarks of FONAR Corporation.

This release may include forward-looking statements from the company that may or may not materialize. Additional information on factors that could potentially affect the company's financial results may be found in the company's filings with the Securities and Exchange Commission.

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